- The receptor of the virus where it invades our body –
In the past four to five months, knowledge of the Covid 19 virus infection has been rapidly iterative, and the method of prevention and treatment is also upgrading accordingly.
We call this disease “new coronavirus (or Covid 19) pneumonia.” But in fact, we found: “Many patients who were critically ill and ultimately lost their lives, many of them are not dying of the lungs failure, but of damage to other organs.” The Washington Post has a lengthy article: “Doctors have found new ways for the virus to attack the human body.”
The new way is that the Covid 19’s target is not only on the lungs, but on the multiple organs. Our previous understanding may have been lung-centric, and other organs were only implicated; but it is not true that other organs of our body are also the target struck by this virus.
Many patients die of stroke or pulmonary embolism, it is because blood clots in our blood vessels that go into the brain or lungs, blocking the blood vessels there. A recent study published in <<The Lancet>> found that one of the direct targets of the Covid 19 is the endothelial (vascular lining) cells of the blood vessels in our bodies. The inner wall of blood vessels is made up of these endothelial cells. The lungs are the most densely populated place for blood vessels. So this may be misleading doctors at first, thinking the virus is attacking the lungs, but in fact it is targeting endothelial cells in the blood vessels.
In an article published last week in the Proceedings of the American Cardiovascular Society, reported in 2,700 cases tracked the death rate for those in critical condition (i.e. those on a ventilator) dropped from 63% percent to 29% after using anticoagulants (substances that prevent blood clotting). The progress of scientific understanding has brought about such an immediate change.
The damages caused by the Covid 19 in the endothelial cells of the blood vessels leads a disorder of the blood coagulation inside the blood vessels i.e. defused intravascular coagulation (DIC). Blood clots formed after damage caused in the lining of the blood vessels. They become blood thrombus reache the brain and lungs end up with a stroke or pulmonary embolism. Mehra, a professor at Harvard Medical School and one of the authors of the Lancet paper, told The Washington Post, “Our initial assumption was that the Covid 19 was thought to be a respiratory virus, but it turned out to be more like a cardiovascular virus.”
This change in perception goes beyond blood vessels. For example, doctors noticed at first: “The patient’s kidneys will be damaged.” But it is widely believed that the problem is the use of ventilators, or the side effects of drugs on the kidneys caused in these critically ill patients. Doctors have come to notice that some patients, even if they have not been admitted to intensive care, have damaged the glomerular balls (where it has dense blood vessels) in their kidneys, the kidney cells that filter the waste. Covid 19 pathogens were found in the kidneys. As a result, scientists are increasingly aware that the Covid 19 may not have spread from the lungs, but from the beginning the kidneys were targeted.
Covid 19, like other coronaviruses have to pass a receptor to invade our bodies. The receptor is ACE2, which is an enzyme made up of proteins. A new coronavirus or SARS actually invades our human cells by attaching it to the surface of ACE2. The surface of the new Covid 19 has dense, hemp protrusions that allow the virus to adhere more steadily to the surface of ACE2. It requires only a smaller number of viral molecules than SARS or MERS to successfully attach to ACE2 invades the human body. This explains why the Covid 19 is more contagious than previous SARS. The receptor ACE2, the receptor of the Covid 19 is found in the lungs, kidneys, and intestines. This explains why virus attack points are primarily in these organs. ACE2 is critical to regulating our body’s blood pressure. The full name of ACE2 is “angiotensin conversion enzyme 2”. This also explains a new finding: Many Covid 19 patients experience elevated blood pressure before their condition worsens.
Our understanding of the virus is still deepening, and our understanding of symptoms and pathological mechanisms is rapidly improving.
There is also good news about medication and treatment for the disease. Some very effective treatments have been developed and have been endorsed by WHO this week, which has been approved by WHO, and says that “there are currently four to five treatment options that are expected to have positive clinical data” and will be rolled out. This includes a combination of anti-inflammatory drugs and blood anticoagulants at Mount Sinai Hospital in New York. A study published in the Lancet found that three antiviral drugs for AIDS, hepatitis C, and multiple sclerosis could reduce the cure time for some patients from about 12 days to 7 days, and the results of the nasopharyngeal swab test can turn negative. But at the same time, drugs that had been expected to be highest are being rapidly replaced because of their poor efficacy. For example, previously President Donald Trump has pushed for hydroxychloroquine, a drug to fight malaria. Because of its toxicity and less significant effect, it has been quickly abandoned by doctors.
Dr. Zhang’s comments:
So to protect the endothelial cells of the blood vessels and stop the development of the Defused intravascular coagulation (DIC) is very important. In conventional medicine it uses anti-inflammation and blood thinning drugs. In our Chinese herbal protocols, we can use Allicin Capsule and Circulation P Capsule to protect the endothelial cells of the blood vessels and stop the DIC.